Prognostic factors for long-term survival in patients with locally invasive pancreatic cancer |
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Authors: | Tani Masaji Kawai Manabu Terasawa Hiroshi Ina Shinomi Hirono Seiko Shimamoto Tetsuya Miyazawa Motoki Uchiyama Kazuhisa Yamaue Hiroki |
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Institution: | (1) Second Department of Surgery, Wakayama Medical University, School of Medicine, 811-1 Kimiidera, Wakayama 641-8510, Japan |
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Abstract: | Background/Purpose We aimed to investigate predictors of survival in patients with resectable locally invasive pancreatic cancer.
Methods The patient cohort consisted of 55 patients with locally invasive pancreatic cancer (International Union Against Cancer UICC]
stage III in 36 patients and stage IV in 19) who had undergone resection. The patients were informed about the advantages
and the adverse effects of postoperative chemotherapy, and prospectively selected either observation alone or postoperative
chemotherapy. The postoperative chemotherapy regimen options were: (1) intraarterial chemotherapy alone, (2) systemic chemotherapy
alone, or (3) intraarterial chemotherapy combined with systemic chemotherapy.
Results Overall 1-year and 2-year survival rates after resection were 40.5% and 13.5%, respectively. Median survival time was 10.9
months. Twenty-nine patients (52.7%) received postoperative chemotherapy. On univariate analysis, only postoperative chemotherapy
was associated with long-term survival (P < 0.01). In the patients with postoperative chemotherapy, the 1-year survival rate and MST were 61.7% and 16.3 months, compared
with 20.1% and 7.9 months in the patients without postoperative chemotherapy. Multivariate analysis also showed that only
postoperative chemotherapy was identified as an independent survival factor.
Conclusions It was suggested that postoperative chemotherapy was essential for the improvement of survival in patients with locally invasive
pancreatic cancer. |
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Keywords: | Locally advanced pancreatic cancer Postoperative chemotherapy Survival |
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