阿奇霉素序贯疗法治疗小儿肺炎支原体肺炎疗效观察

目的观察阿奇霉素序贯疗法治疗小儿肺炎支原体肺炎的临床效果。方法深圳市宝安区福永人民医院2013年6月至2014年8月收治肺炎支原体肺炎患儿96例,随机分为对照组和观察组各48例。对照组采用红霉素序贯疗法,给予红霉素注射液静脉滴注,每日1次,持续治疗5d后,改用红霉素片口服,每日3次,持续治疗7d。观察组采用阿奇霉素序贯疗法,给予阿奇霉素注射液静脉滴注,每日1次,治疗5d后,停药4d,改为阿奇霉素干混悬剂口服,每日1次,持续给药3d。观察两组患儿治疗效果及不良反应发生情况。结果观察组患儿总有效率为97.9%(47/48),高于对照组85.4%(41/48),差异有统计学意义(P0.05)。观察组不良反应发生率为14.6%(7/48),低于对照组27.1%(13/48),差异有统计学意义(P0.05)。结论在小儿肺炎支原体肺炎治疗中,阿奇霉素序贯疗法能明显改善临床症状,具有见效快、不良反应少等优势,疗效安全显著,最大程度减轻患儿痛苦,提高患儿生活质量,值得临床推广应用。

Observation of clinical effects of azithromycin sequential therapy for children with mycoplasma pneumonia

Objective To observe the clinical effects of azithromycin sequential therapy for children with mycoplasma pneumonia.Methods Totally 96 children with mycoplasma pneumonia who received treat-ments in Fuyong People's Hospital from June 2013 to August 2014 were taken as the research subjects,and these patients were randomly divided into the control group and the observation group,with 48 patients in each group.In the control group,they were treated with the erythromycin sequential therapy:erythromycin injection was administered intravenously once a day,continuously for 5 days,and then they were treated with the erythromycin tablets orally,3 times a day,continuously for 7 days;in the observation group,they were treated with the azithromycin sequential therapy,azithromycin injection for intravenous drip,once a day,and 5 days later the treatment was stopped for 4 days,and then azithromycin dry suspension was given orally, once a day,continuously for 3 days.Then,the treatment effect and adverse reaction of the two groups were observed.Results The total effective rate in observation group was 97.9%(47/48),which was higher than that in the control group [85.4%(41/48)],and the difference was statistically significant(P <0.05).The incidence rate of adverse reactions in the observation group was 14.6% (7/48),which was lower than that in the control group [27.1%(13/48)],and the difference was statistically significant(P < 0.05 ).Conclusion In the treatment of children with mycoplasma pneumonia,the azithromycin sequential therapy can significantly improve the clini-cal symptoms,and it has quick effect and fewer adverse reactions with other advantages;it is safe with signif-icant effect and it can greatly reduce the pain and improve the quality of life of children,thus it should be promoted in the clinical application.