中国城市儿童性早熟现状的调查研究

目的对国内城市儿童性早熟现状进行调查,为制定有效的预防策略,并推动儿童性早熟的临床规范化和个性化治疗提供理论依据。方法 2014年3月至12月在全国范围内开展"中国城市儿童性早熟现状调研"活动。调研共收集来自全国10余省市的2 687份问卷,其中1 714份问卷纳入统计分析。结果调查人群大多分布在全国10个主要省市,包括北京、上海、重庆、江苏、湖北等;调查患儿以女童为主,其男女比例约1∶16。诊断为中枢性性早熟的患者占75.79%(1 299/1 714);调查中初次诊断为中枢性性早熟患者占88.91%(1 524/1 714)。调查患者的骨龄为(10.00±1.77)岁,高于实际年龄(8.29±1.60)岁,差异有统计学意义(P0.001);初次诊断为CPP的患者的骨龄为(10.11±1.70)岁,高于实际年龄(8.35±1.57)岁,差异均有统计学意义(P0.001)。结论国内城市儿童性早熟就诊患者的年龄偏大,为防止患者就诊时已错过最佳的干预和治疗时机,应引起对疾病筛查的高度重视,做到早发现、早诊断和早治疗。

The status survey of children with precocious puberty in Chinese cities

Objective To investigate the status of patients with precocious puberty in Chinese cities,and provide a theoretical basis for making effective prevention strategy,and promoting clinical standardization and per-sonalized treatment of precocious puberty.Methods "Precocious Puberty Research in Chinese cities" activities be-gan in the period between March and December 2014.Among a total of 2 687 questionnaires,1 714 were included in the final statistical analysis.Results The survey of patients with city distribution were mainly in 10 cities,the top three being Chongqing(21.28%),Changzhou(9.26%)and Shanghai(8.37%).Girls dominated the survey,and male to female ratio was about 1 ∶16;In secondary inspection,patients diagnosed with central precocious puberty accounted for 75.79% by GnRH stimulation test.Initial diagnosis of patients with central precocious puberty ac-counted for 88.91%.In all patients with central precocious puberty,bone age was higher than the actual average age at about 1.65 years old and the differences were statistically significant(P <0.001).Conclusion The patients with central precocious puberty in Chinese cities are generally older.In order to avoid missing the best time for interven-tion and treatment,great importance should be attached to the disease screening,and early detection,early diagnosis and early treatment must be done.