不孕症患者血清免疫性抗体检测的临床价值与治疗体会

目的研究不孕症患者血清免疫性抗体检测的临床价值。方法选取吉林省人口生命科学技术研究院2013~2014年收治的不孕症患者150例为观察组,正常生育妇女150例为对照组,观察组患者给予肾上腺皮质激素类和隔绝疗法进行治疗。比较两组治疗前抗精子抗体(Antisperm antibody,As Ab)、抗子宫内膜抗体(Endometrial antibody,EMAb)、抗卵巢抗体(antiovary antibody,Ao Ab)、抗透明带抗体(Anti zona pellucida antibodies,Azp Ab)阳性比例的差异和观察组治疗前后的变化情况,并评价疗效。结果观察组治疗前As Ab阳性、EMAb阳性、Ao Ab阳性、Azp Ab阳性的例数(34、17、11、10)均高于对照组(2、1、1、1)(P0.05);观察组治疗后As Ab阳性、EMAb阳性、Ao Ab阳性、Azp Ab阳性的例数(19、7、3、3)低于治疗前(34、17、11、10)(P0.05)。观察组治疗后自然受孕和人工受孕的例数高于治疗前的例数(8 vs 0,16 vs 0)(P0.05)。结论免疫抑制治疗不孕有良好的效果,通过检测和分析自身免疫抗体的变化诊断和治疗不孕症具有可行性,值得临床推广应用。

Clinical value of serum immune antibody detection in infertile patients and treatment experiment

Objective To study the clinical value of serum immune antibody detection in infertile patients. Methods 150 infertile patients who were treated in population life science and technology institute of Jilin province from March 2013 to March 2015 were selected as observation group, and 150 normal reproductive women were selected as control group. The observation group was treated with adrenal cortical hormone and isolated therapy. The differences of positive rate of AsAb, EMAb, AoAb and AzpAb of two groups before treatment were compared, and in order to investigate the effect of treatment, a contrast observation of AsAb, EMAb, AoAb and AzpAb of oberservation group was made. Results The rates of AsAb positive, EMAb positive, AoAb positive and AzpAb positive of observation group were higher than those of the control group(P<0. 05). The rates of AsAb positive, EMAb positive, AoAb positive and AzpAb positive in the observation group declined after treatment. (P<0. 05). The number of pregnant cases naturally or assisted in the observation group after treatment increased. (P<0. 05). Conclusion Immunosuppressive therapy has a good effect for infertility, and it is feasible to diagnose and cure infertility by testing and analyzing the change of the autoimmune antibody. This therapy is worthy of clinical promotion and application.