iNOS在胃黏膜相关淋巴组织淋巴瘤中的表达及临床意义

目的 探讨诱导型一氧化氮合酶（inducible nitric oxide synthase，iNOS）在胃黏膜相关淋巴组织淋巴瘤中的表达及临床意义。方法 用Evision两步法免疫组化检测31例胃黏膜相关淋巴组织淋巴瘤及其癌旁正常组织中的iNOS表达，并分析其与胃黏膜相关淋巴组织淋巴瘤临床病理特征的关系。结果 iNOS在胃黏膜相关淋巴组织淋巴瘤中的表达水平明显高于癌旁正常组织，iNOS在胃黏膜相关淋巴组织淋巴瘤及癌旁正常组织中的阳性表达率分别为64.5%（20/31）和29.03%（9/31）。iNOS的表达与临床分期、幽门螺杆菌（Helicobacter pylori，Hp）感染相关（P<0.05）；而与年龄、性别、LDH水平无关（P>0.05）。结论 iNOS可能参与胃黏膜相关淋巴组织淋巴瘤的发生、发展，可作为评估其生物学行为的指标。

Expression of iNOS in gastric mucosa-associated lymphoid tissue lymphoma carcinoma and its clinical significance

Objective To explore the expression and its clinical significance of inducible nitric oxide synthase（iNOS） in gastric mucosa-associated lymphoid tissue （MALT） lymphoma. Methods Immunohistochemistry was used to detect iNOS expression in tissue sections from 31 gastric MALT lymphomas and paired adjacent tissues. Then possible relationships were explored between iNOS expression and clinicopathological variables. Results The rate of high expression of iNOS was significantly higher in MALT lymphoma tissue （64.5%） than in paired adjacent tissues （29.03%，P<0.05）. Level of iNOS expression correlated with Ann-Arbor clinical stage and Helicobacter pylori（P<0.05），but not with gender，age or lymph node metastasis（P>0.05）. Conclusion  Expression of iNOS may contribute to the occurrence and development of gastric MALT lymphoma. This protein may serve as a biomarker for evaluating tumor behavior in patients with this disease.