儿童过敏性紫癜临床症状与紫癜性肾炎的相关性研究

目的探讨儿童过敏性紫癜临床症状与紫癜性肾炎的相关性。方法 2013年5月至2015年4月深圳市宝安区妇幼保健院儿科收治住院的过敏性紫癜患儿200例,根据是否并发肾炎分为肾炎组109例和非肾炎组91例。对两组患儿的年龄及临床症状(皮疹反复发作时间、消化道出血、腹痛、关节痛、血管水肿性水肿)进行单因素及Logistics多因素分析。结果单因素分析结果显示,儿童过敏性紫癜肾炎与年龄、皮疹反复发作时间、消化道出血、腹痛、关节痛明显相关(P0.01);经Logistics非条件多因素分析结果显示,年龄≥8岁、皮疹反复发作时间≥4周、消化道出血、腹痛、关节痛是引发儿童过敏性紫癜肾炎的独立危险因素(P0.01)。结论儿童过敏性紫癜肾炎的产生与临床症状密切相关,其中年龄≥8岁、皮疹反复发作时间≥4周、消化道出血、腹痛、关节痛是引发紫癜性肾炎的独立危险因素。

Research on the relationship between clinical symptoms of allergic Henoch-Schonlein purpura and purpura ne-phritis in children

Objective To investigate the relationship between clinical symptoms of children with allergic purpura and Henoch-Schonlein purpura nephritis in children.Methods Totally 200 cases of children with allergic purpura treated in the Department of Women and Children Health Care Hospital of Baoan District of Shenzhen city from May 2013 to April 2015 were divided into two groups:purpura nephritis group(109 cases)and non-nephritis group(91 cases)according to whether or not having concurrent nephritis.The age and clinical symptoms of the two groups were analyzed by single factor and Logistics multi-factor analysis(recurrence time of rash,bleeding of diges-tive tract,abdominal pain,joint pain,and edema of the blood vessels).Results Single factor analysis showed that children with allergic purpura nephritis was significantly related to age,recurrence time of skin rash,digestive tract bleeding,abdominal pain and joint pain(P <0.01).The logistics non-conditional multivariate analysis showed that age,which is more than or equal to 8 years old,time period of recurrent rash,which is more than or equal to 4 weeks,digestive tract bleeding,abdominal pain and joint pain were the independent risk factors for children with al-lergic purpura nephritis(P <0.01).Conclusion The development of allergic purpura nephritis is closely related to the clinical symptoms.Age,which is more than or equal to 8 years old,time period of recurrent rash,which is more than or equal to 4 weeks,digestive tract bleeding,abdominal pain and joint pain are independent risk factors for pur-pura nephritis(HSPN).