卵巢多囊样改变对体外受精-胚胎移植结局的影响

目的探讨卵巢多囊样改变(polycystic ovaries,PCO)伴不孕患者体外受精-胚胎移植(in vitro fertilization andembrgo transfer,IVF-ET)治疗的效果。方法回顾性分析2011~2014年首都医科大学附属北京妇产医院因输卵管因素行IVF助孕的PCO患者180例,同期180例因输卵管因素行IVF助孕的非PCO患者为对照组,对两组患者的基本情况和治疗结局进行统计分析。结果与对照组相比,PCO组促性腺激素(gonadotropin,Gn)用量少,绒毛膜促性腺激素(Human chorionic gonadotropin,HCG)日血清雌二醇(estrodiol,E2)高,获卵数较多。两组受精率、优质胚胎率和临床妊娠结局等比较差异无统计学意义(P0.05)。结论单纯PCO合并输卵管性不孕的患者行IVF具有良好的结局,但应警惕卵巢过度刺激综合征(ovarian hyperstimulation syndrome,OHSS)的发生。

Effects of polycystic ovaries on the outcomes of in vitro fertilization -embryo transfer

Objective To explore the effects of in vitro fertilization-embryo transfer ( IVF-ET ) in patients with polycystic ovaries( PCO) complicated with infertility. Methods 180 PCO patients with tubal factors receiving IVF from 2011 to 2014 were analyzed retrospectively, and the control group consisted of 180 patients with tubal factor infertility but without ovary disease, generally characteristics and clinical outcomes of two groups were analyzed. Results In PCO group, the dosage of gonadotropin administration was significantly smaller, the estrodiol on Human chorionic gonadotropin ( HCG ) day and the number of oocytes retrieved were significantly higher. There were no significantly differences between fertilization rate, rate of high quality embryos and clinical pregnancy outcomes. Conclusion Polycystic ovaries patients complicated with tubal factor infertility have good consequences through IVF, but more attention should be paid in case of the occurrence of ovarian hyperstimulation syndrome ( OHSS) .