孟鲁司特钠对婴幼儿喘息的早期干预及预防哮喘发生的临床研究

目的观察孟鲁司特钠咀嚼片早期干预治疗对婴幼儿喘息发作的治疗效果以及喘息后哮喘等影响。方法 2013年1月至2015年1月苏州市立医院儿科收治住院的婴幼儿喘息患儿96例,随机分成观察组和对照组各48例。对照组给予常规综合治疗,观察组在对照组治疗基础上给予孟鲁司特钠咀嚼片,观察短期疗效、临床症状评分,随访1年半内的哮喘发生率。结果观察组总有效率为93.75%(45/48),显著高于对照组79.17%(38/48),差异有统计学意义(P0.05)。治疗后观察组患儿喘息、咳嗽、哮鸣音以及痰鸣音评分显著低于对照组,差异有统计学意义(P0.05)。观察组1年半内喘息发作次数明显少于对照组,平均每次持续时间也显著短于对照组,差异有统计学意义(P0.05);随访1年半,观察组哮喘发生率为8.33%(4/48),明显低于对照组22.92%(11/48),差异有统计学意义(P0.05)。两组患儿均无明显的不良反应发生。结论孟鲁司特钠咀嚼片早期干预治疗提高了治疗效果,缓解了急性发作期临床症状,降低了喘息后哮喘的发生率。

Clinical study of Montelukast early intervention on severity of wheezing in infants and prevention of the devel-opment of asthma

Objective To study the effect of Montelukast early intervention in wheezing of infants and in the prevention of asthma.Methods Between January 2013 and January 2015,96 pediatric patients with wheezing were admitted to the Suzhou Municipal Hospital,and they were divided randomly into observation group and control group,each with 48 cases.The control group was treated with conventional therapy, while Montelukast sodium chewable tablets were given in observation group on the basis of treatment for control group.Observe the short-term effect and the clinical symptom score,and the incidence of asthma was followed up for 1.5 years.Results The total short-term rate was 93.75% in observation group and which was significantly higher than that of control group(79.17%),the difference being significant(P <0.05).After treatment,symptom scores for observation group significantly reduced,which were signifi-cantly lower than the control group,the difference being significant(P <0.05).Wheezing episodes for the observation group were significantly fewer than the control group,and the average duration was significantly shorter than the control group within 1 and a half years,the difference being significant(P <0.05).After 1 and a half years of follow-up,the incidence of asthma in the observation group was significantly lower than the control group,the difference being significant(P <0.05).No obvious adverse reaction occurred in both groups.Conclusion Montelukast early intervention can improve outcomes,alleviate clinical symptoms of a-cute exacerbation and reduce the incidence of asthma after wheezing.