血清纤维化指标联合肝功能指标检测用于诊断慢性肝脏疾病的临床观察

目的研究血清纤维化指标联合肝功能指标检测用于诊断慢性肝脏疾病的临床价值。方法病例选取2011年6月至2013年6月我院接诊的80例慢性肝脏疾病患者进行研究,并选择40例正常人作为正常组进行对照研究。检测分析血清纤维化指标和肝功能指标,并评定慢性肝脏疾病的阳性检出率。结果联合检测的阳性检出率(93.75%)明显高于纤维化指标检测(67.50%)和肝功能指标检测的阳性检出率(75.00%),比较有显著性差异(χ2=17.479 0,P=0.000 2)。慢性肝脏疾病患者的丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)均明显升高(P<0.01);肝硬化和肝癌患者的甲胎蛋白(AFP)均出现明显升高(P<0.01);透明质酸(HA)、Ⅳ型胶原(Ⅳ-C)及型前胶原(PCⅢNP)均出现明显升高(P<0.01)。结论血清纤维化指标联合肝功能指标检测用于诊断慢性肝脏疾病的临床价值较高,值得临床推广应用。

Clinical Observation of the Combined Detection of Serum Fibrosis Indexs and Liver Function Indexs for the Diagnosis of Chronic Liver Diseases

Objective To study the clinical value of serum fibrosis indexs combined with liver function indexs for the diagnosis of chronic liver diseases. Methods 80 patients with chronic liver diseases from June 2011 to June 2013 in our hospital were selected to study. And 40 healthy adults were selected as the control group. The primary outcome was results of the detection of the serum fibrosis indexs and liver function indexs;and the secondary result was an analysis of the positive rate of chronic liver disease. Results The positive rate of joint detection （93.75%） was significantly higher than the fibrosis index detection （67.50%） and the liver function indexs testing positive rate （75.00%） , with significant difference （χ^2=17.479 0, P=0.000 2）. The alanine aminotransferase （ALT）, aspartate aminotransferase （AST） of the patients with chronic liver diseases were significantly increased （P〈0.01）;the alpha-fetoprotein （AFP） of the patients with cirrhosis and liver cancer were significantly boosted （P〈0.01）. The hyaluronic acid （HA）, type Ⅳ collagen （Ⅳ-C） and PCⅢNP of the patients with chronic liver diseases significantly increased （P 〈0.01）. Conclusions The combined detection of serum fibrosis indexs and liver function indexs for the diagnosis of chronic liver disease has high clinical value for diagnosing chronic livers diseases, which is worthy of wide clinical application.