精液中圆形细胞对宫腔内人工受精妊娠率的影响

目的探讨精液中圆形细胞对宫腔内人工受精（IUI）妊娠率的影响。方法分析2012年1月-2012年12月在我中心行IUI治疗的不孕患者精液情况1293个治疗周期，其中选择标准是处理前的精液液化时间≤60mim，处理后活动精子总数（PTMS）〉5×10-6／ml的患者，根据处理前精液中圆形细胞浓度分成3组：I组，≤1×10-6／ml；Ⅱ组，〉1×10-6／ml，≤5×10-6／ml；Ⅲ组〉5×10-6／ml。比较各组间的精液参数和IUI妊娠率。结果1293个IUI周期共获得181例妊娠，总周期妊娠率是14．00％。精液中圆细胞浓度大于5×10-6／ml组妊娠率极显著低于其它两组，（OVSl3．4％；0VS27．86％，P〈0．01）。而在流产率组Ⅰ组Ⅱ均差异不显著（P〉0．05）。结论在IuI治疗周期中处理前精液中圆细胞浓度大于5×10-6／ml时可能会是影响妊娠率的重要因素。

Effect of intrauterine insemination on round cell in semen.

Objective： To analyze the effect on pregnancy outcome used semen containing round cell after intrauterine insemination. Methods： There are 1293 intrauterine insemination cycles between January to December on 2012 in our fertility center. Ejaculates containing≤60mim the time of semen Liquefaction and 〉 5×10-6/ml processed total motile sperm count （PTMS） were used in this study. According to the concentration of round cell in semen, the semen were divided into 3 groups （ ≤1×10-6/ ml; 〉l×l06/ml and ≤5×10-6/ml; 〉5×10-6/ml） . Meanwhile the parameters and IUI outcome were compared among the 3 groups. Results- Pregnancy occurred in 181 cycles and a cycle fecundity of 16.67% in 1293 cycles. Compared to other group, there was significant difference was found in PTMS〉5×l0-6/ml group （0 VS.13.4%; 0 VS. 27.86%, P〈0.01） . In the abortion rate group ⅡⅠ group were difference was not significant （P〉 0.05） . Conclusion： Therefore, it maybe play an important role in IUI pregnancy outcome existed in the concentration of round cell in ejaculates.