湖州市结核病耐药情况的比较研究

目的：分析湖州市实施现行结核病控制策略对耐药变迁状况的影响。方法收集2001-2004年（第1次监测）和2009年7月-2010年6月（第2次监测）湖州市各县（市、区）结核病新登记痰培养阳性并鉴定为结核分枝杆菌的结核病患者标本192和772份，培养阳性菌株标本做药敏试验，药敏试验采用比例法。结果第1次监测与第2次监测相比，总耐药率由25.25％下降至15.41％，差异有统计学意义（P＜0.01）；总耐多药率由6.88％下降至3.50％，差异有统计学意义（P＜0.01）；获得性耐药率自51.30％下降至43.02％，差异无统计学意义（P＞0.05）；初始耐药率由19.02％下降至11.95％，差异有统计学意义（P＜0.01）。结论现行结核病控制策略实施下，结核病耐药率有所下降。

A comparison study on the multi-drug resistance of tuberculosis in Huzhou City

Objective To obtain the data on total drug resistance rate,initial drug resistant rate and acquired drug resistant rate and to analyze the efficacy of modern tuberculosis control strategy in Huzhou City.Methods Collect sputum specimens which were cultured positive from mycobacterium tuberculosis patients with new registration and identification in Huzhou in the first stage （2001-2004）and second stage （2009-2010）.The sample size was 192 and 772 respectively. We used cultured positive specimens for drug sensitivity test which was by means of proportion method.Results In the first stage （2001-2004 ）,the rate of total drug resistance,multi -drug resistance,initial resistance and acquired resistance was 25.25%,6.9%,19.02% and 51.30% respectively.The rates above in the second stage （2009-2010） were 15.41%,3.50%,1 1.95% and 43.02% respectively.There was significant difference （P〈0.01 ）in the rates of total drug resistance,multi-drug resistance and initial resistance between the two stages,but no significant difference （P〉0.05 ） in the rate of acquired resistance. Conclusion Modern tuberculosis control strategy makes noticeable achievements for the drug resistant tuberculosis control,but the acquired drug resistance remains to be the focus of tuberculosis prevention and control in the current strategy.