混合型肝癌患者临床特点及预后相关因素研究

目的探讨混合型肝癌患者的临床特点及其预后等相关因素。方法回顾性分析我院2010～2013年收治的48例混合型肝癌患者及其临床诊断资料，并统计和分析其临床病理特点、诊断及预后。结果全组48例患者以男性居多，为34例（70．8％）；结合完整随访资料（40例）来看，术后1年生存率为62．5％（25／40），1．5年为30．0％（12／40）和3年为22．5％（9／40）。经单因素生存分析。烟酒史、侵犯肝被膜为平均无进展时间（PFS）的主要相关因素，烟酒史、侵犯肝被膜和肿瘤多发，以及切缘阳性等为总生存时间（OS）的主要相关因素。结论烟酒史、侵犯肝被膜、切缘阳性和肿瘤多发等是影响混合型肝癌预后的主要因素。临床需予以重视。

Study on the Clinical Characteristics and Prognosis Related Factors of Patients with Combined Hepatocellular Carcinoma and Cholangiocarcinoma

Objective To investigate the clinical characteristics and prognosis related factors of combined hepatocellular carcinoma and cholangiocarcinoma （cHCC-CC）. Methods 48 patients with cHCC-CC in our hospital from 2010 to 2013 and their diagnosis data were retrospectively analyzed, and the clinical pathological characteristics, diagnosis and prognosis were calculated and analyzed. Results In all of 48 cases, 34 cases （70.8%） were male. Among 40 cases of follow-up, the 1-year survival rate was 62.5% （25/40）, 1.5-year survival rate was 30.0% （12/40） and 3-year survival rate was 22.5 （9/40）. The single factor survival analysis showed that history of tobacco and alcohol, violation of the liver capsule were the main relative factors of progression free survival （PFS）, history of tobacco and alcohol, violation of the liver capsule, multiple tumors, and positive margin were main relative factors of overall survival （OS）. Conclusions The history of tobacco and alcohol, violation of the liver capsule, multiple tumors, and positive margin are main factors of prognosis of cHCC-CC, which need clinical attention.