| 超微孔膨体聚四氟乙烯在家兔体内的钙化及生物力学特性研究 |
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| 引用本文： | 李海波,王武军,蔡开灿,王振康,梁永,邵亚辉. 超微孔膨体聚四氟乙烯在家兔体内的钙化及生物力学特性研究[J]. 南方医科大学学报, 2003, 23(5): 445-448 |
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| 作者姓名： | 李海波 王武军 蔡开灿 王振康 梁永 邵亚辉 |
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| 作者单位： | 1. 第一军医大学南方医院胸心血管外科,广东,广州,510515
2. 第一军医大学南方医院心血管内科,广东,广州,510515 |
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| 基金项目： | 广东省科委重点攻关项目(99B06702G)~~ |
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| 摘 要： | 目的观察超微孔膨体聚四氟乙烯(UePTFE)在家兔体内钙化及生物力学特性改变,并与临床常用的牛心包生物瓣材料(BP)进行比较,以阐明其作为新型人工心脏瓣膜材料的可行性。方法实验设计采用析因分析的方法,将超微孔膨体聚四氟乙烯材料及牛心包生物瓣材料裁成适合大小埋植于新西兰幼兔皮下,分别于0、1、3、6月时取出材料,测定钙含量及生物力学指标,进行对比。结果超微孔膨体聚四氟乙烯材料较牛心包生物瓣材料钙化慢且程度轻,各项力学指标优于牛心包生物瓣材料。结论超微孔膨体聚四氟乙烯材料可以作为制作人工心脏瓣膜的材料。
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| 关 键 词： | 膨体聚四氟乙烯 生物瓣 钙化 生物力学 人工心脏瓣膜 |
| 文章编号： | 1000-2588(2003)05-0445-04 |
| 修稿时间： | 2003-01-10 |
Calcification and biomechanics in vivo of ultra-microporous expanded polytetrafluoroethylene in rabbits |
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| LIHai-bo,WANGWu-jun,CAIKai-can,WANGZhen-kang,LIANGYong,SHAOYa-huiDepartmentofCardiothoracicSurgery,DepartmemtofCardiology,NanfangHospital,FirstMilitaryMedicalUniversity,Guangzhou,China. Calcification and biomechanics in vivo of ultra-microporous expanded polytetrafluoroethylene in rabbits[J]. Journal of Southern Medical University, 2003, 23(5): 445-448 |
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| Authors: | LIHai-bo WANGWu-jun CAIKai-can WANGZhen-kang LIANGYong SHAOYa-huiDepartmentofCardiothoracicSurgery DepartmemtofCardiology NanfangHospital FirstMilitaryMedicalUniversity Guangzhou China |
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| Affiliation: | LIHai-bo1,WANGWu-jun1,CAIKai-can1,WANGZhen-kang1,LIANGYong1,SHAOYa-hui2DepartmentofCardiothoracicSurgery1,DepartmemtofCardiology2,NanfangHospital,FirstMilitaryMedicalUniversity,Guangzhou510515,China |
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| Abstract: | Objective To study in vivo calcification and biomechanic s of the ultra-microporous expanded polytetrafluo-roethylene (UePTFE) in ra bbits in comparison with glutaral-treated bovine pericardium (BP), so as to asse ss the potential of UePTFE as a material for cardiac valve prosthesis. Method F actorial analysis was adopted in the experiment. UePTFE and glutaral-treated BP of appropriate sizes were embedded beneath skin of young New Zealand rabbits, a nd at 0, 1, 3 and 6 months following the implantation, the materials were measu red for the content of calcium and biomechanics properties. Results Lower level of calcification of the UePTFE occurred after the implantation, as compared with BP, and the biomechanics indices of the former UePTFE were obviously suprior t o those of the latter. Conclusion UePTFE is a better material than BP for card iac valve prosthesis. |
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| Keywords: | expended polytetrafluoroethylene bioprosthesis v alve calcification biomechanics cardiac valve prosthesis |
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