危重患者质子泵抑制药的预防性使用概述

摘 要质子泵抑制药（PPI）因其强大而持久的抑酸作用，目前已成为临床常用药物之一。危重患者应激性溃疡发生率较高,且并用药物较多，PPI在危重患者中的使用尤为重要。目前已有研究表明，PPI在危重患者中的使用可能带来不良的后果（如艰难梭菌感染相关性腹泻、肺炎等），在危重患者中合理使用PPI也显得非常重要，尤其是PPI的预防性使用。现就PPI在危重患者中预防药物所致上消化道损伤及预防应激性溃疡作一综述，以期为危重患者合理使用PPI提供参考。

Preventive Use of Proton Pump Inhibitors in Critical Patients

ABSTRACTProton pump inhibitors (PPI) have been widely used in clinics because of strong and lasting inhibiting effect on gastric acid secretion. Because of the higher incidence of stress ulcer and more drug combination used in critical patients, the use of PPI is more important. It has been proved that PPI used in critical patients may increase the incidence of serious adverse events, such as clostridium difficile associated diarrhea and pneumonia, so the rational use of PPI is more important in critical patients, especially for the preventive use. The preventive use of PPI including the prevention of drug related upper gastrointestinal damage and stress ulcer in critical patients was reviewed in the paper in order to provide reference for the rational drug use.