成人斯蒂尔病109例临床分析

目的探讨成人斯蒂尔病的发病、临床特点及治疗、预后转归情况.方法回顾性分析109例成人斯蒂尔病患者的临床资料.结果成人斯蒂尔病长期临床控制者为26.60%,周期性反复发作者为62.38%,演变为类风湿关节炎者为5.50%,平均时间为5.2年,演变为淋巴瘤者为0.92%,死亡4.59%.结论成人斯蒂尔病大部分为周期性反复发作型,血清学无特异性检查,血清铁蛋白的测定有助于本病的诊断.患者累及关节以腕关节最常见.小部分患者最终演变为典型的类风湿关节炎.非甾体类消炎药对大部分患者无效,需用激素,甚至免疫抑制剂控制病情.

Clinical analysis of 109 patients with adult-onset Still''''s disease

Objective To investigate clinical features and therapeutic measures of adult onset Still's disease(AOSD),and to find out its transformations.Methods Analysing retrospectively 109 patients with AOSD in Peking Union Medical College Hospital from 1983 2000.Results 26.60 percent of the patients investigated were clinical recovered,62.38 percent in repeated attack,5.50 percent transformating into RA in the mean course of 5.2 years,0.92 percent transformating into lymphoma and 4.59 percent died.Conclusions Major patients investigated appeared repeated attack periodically.No specific serum indication was found,but the determination of serum ferrin is helpful to diagnosis of the disease.Minority of the disease transformate into typical RA with usually wrist joint involved.NSAIDs is ineffective on major patients with adult onset Still's disease,and hormone,even immunosuppressant is needed for controlling disease.