大鼠肝移植术后并发症的预防

目的 探讨大鼠肝移植术后并发症的预防措施.方法 比较建立模型初期所行50例大鼠肝移植前20例(前组)与后30例(后组)的手术时间、无肝期、手术成功率、术后生存率及并发症.结果 与前组相比,后组供体手术时间、供体修整与套管安装时间、无肝期及受体手术时间明显缩短(P＜0.05),手术成功率与术后3 d及7 d生存率明显提高(P＜0.05),早期术后出血并发症明显减少(P＜0.05),但胆道并发症差异无统计学意义(P＞0.05).结论 掌握大鼠肝移植技术存在明显的学习曲线,熟练的手术操作及术后并发症的合理预防可提高手术成功率及术后大鼠生存率.

Preventive measures of postoperative complications in rat liver transplantation

Objective To explore the preventive measures of complications after orthotopic liver transplantation (OLT) in rats. Methods The outcome of fifty OLTs was analyzed. The operation time, the anhepatic phase, the success rate of operation, the 3-day and 7-day survival rates and the postoperative complications of the former 20 operations the were compared with those of the latter 30 ones. Results Compared with the former group, the donor operation time, the donor-repairing and cuff-installing time, the anhepatic phase and the recipient operation time of the latter group were significantly shorter(P<0.05); The success rate of the OLT and the 3-day/7-day survival rates were significantly increased(P<0.05); Early postoperative bleeding complication was significantly reduced (P<0.05), but there was no difference in the biliary complication(P >0.05). Conclusion It is a learning curve to grasp the technique of OLT in rats. The skilled technique and the reasonable precautions of postoperative complications can increase the success rate of the OLT and the postoperative survival.