肝切除术加化疗治疗原发性肝癌的分析

目的:探讨肝切除加化疗治疗原发性肝癌的疗效。方法:回顾性分析我院1996年1月~2003年12月收治的380例肝癌患者的临床资料,根据不同方法分成2组:手术切除组(A组)130例,手术切除加化疗组(B组)250例。结果:手术切除加化疗组1、3和5年的复发率分别为21.2%、35.1%和45.3%,其1、3和5年累积生存率分别为68.2%、50.1%和21.8%,明显高于单纯手术切除组。术后化疗次数是影响手术切除疗效的重要因素。结论:肝切除术后加区域性化疗可降低肝癌术后复发率,提高了患者的生存率。

Treatment evaluation of hepatectomy and chemotherapy for primary liver cancer

Purpose:To explore the therapeutic effects of h epatectomy and chemotherapy of primary liver cancer(PLC) Methods:The clinical data of 380 PLC patients admitted from Jan uary, 1996 to December, 2003 were divided into two groups: 130 cases underwent h epatectomy (group A), 250 cases underwent hepatectomy and chemotherapy (B group) . Results:The 1-,3-and 5-year recurrence rates in the hepatect omy and chemotherapy group were 21.2%,35.1% and 45.3%. The 1, 3 and 5-y ear overall survival rates in the hepatectomy and chemotherapy group were 68.2%, 50.1% and 21.8%, which were significantly higher than hepatectomy group. The number of chemotherapy courses affected the effect of hepatectomy. Conclusions:Hepatectomy and regional chemotherapy may decrease tumor recurrence rates and improve the disease-free survival rates in patients with PLC.