Nitric oxide in atherosclerosis |
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| Authors: | Rekka E A Chrysselis M C |
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| Affiliation: | Department of Pharmaceutical Chemistry, School of Pharmacy, Aristotelian University of Thessaloniki, Thessaloniki, 54124, Greece. xriselis@pharm.auth.gr |
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| Abstract: | *NO is produced endogenously from L-arginine by NOSs. Among its multiple activities, the homeostatic control of the vascular endothelium is crucial for atherosclerosis, a pathogenic condition connected with elevated levels of LDL, the main plasma cholesterol carrier. Oxidised LDL is proatheromatic, and toxic peroxidation products contribute to further endothelial damage. *NO controls vascular tone, inhibits LDL oxidation and has hypocholesterolaemic activity. This review is referred to the chemistry, biology and role of *NO on atherosclerosis and its treatment by *NO donors or modulators. |
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