精神分裂症患者长期应用抗精神病药治疗后肝脏及血脂变化情况分析

目的 研究精神分裂症患者长期应用抗精神病药治疗后肝脏及血脂变化情况。 方法 搜集并分析自从2012年12月—2013年12月接受治疗的120例精神分裂症患者的资料，进行整理分组。其中将服用抗精神病药在5年以上的75例分为观察组，服用抗精神药物在5年以下的45例患者的分为对照组。另外选取80名健康志愿者设为健康组。同期对这3组进行B超和血脂检测，对其结果进行分析。 结果 观察组患者的肝脏检测异常阳性率(37.33%)较对照组(26.67%)和健康组(3.80%)高，差异具有统计学的意义(P＜0.05)。观察组患者的脂肪肝人数(24.00%)较对照组多，且观察组患者的重度脂肪肝(8.00%)较对照组严重。对照组患者脂肪肝人数及重度脂肪肝人数与健康组相比较高。观察组患者的血脂增高(18.67%)较对照组(11.11%)和健康组(3.75%)高。观察组患者中，中老年(≥55岁)和病程较长(≥7年)的脂肪肝检出率较高，分别为38.89%和35.71%，差异具有统计学的意义(P＜0.05)。 结论 抗精神病类药物对精神分裂症有较好的治疗效果，但是长期服用会使患者发生脂肪肝，患者脂肪肝的发生率明显增加，血脂水平增高，所以应对长期服用抗精神病药物的患者给予及时的检测及预防措施。 

Liver damage and level of blood fat in schizophrenia patient after long-term antipsychotic treatment

Objective To study the changes blood fat level and liver damage in schizophrenia patients after the long-term application of antipsychotic agents. Methods The clinical data of 120 cases of schizophreniain our hospital from December 2012 to December 2013 were collected.75 patients taking antipsychotic drugs more than 5 years were assigned into the observation group,while 45 patients taking antipsychotic drugs less than 5 years were assigned into the control group.Eighty healthy volunteers were recruited as healthy group.B ultrasound and blood lipid detection were performed in all 3 groups. Results The incidence of liver damage in the observation group(37.33%) was higher than that in thecontrol group(26.67%) and health group(3.80%),the difference was statistical significance(P<0.05).The cases with fatty liver in the observation group(24%) were more than that in the control group,and so were the number of severe fatty liver(8%).The incidence of fatty liver and severe fatty liver in the control group was higher than those in thehealthy group.The cases with an elevated blood fat in the observation group(18.67%) were more than the control group(11.11%) and healthy group 3.75%).In the observation group,the middle and old patients(more than 55 years) or with a longer course(more than 7 years) were with a higher incidence of fatty liver(38.89% and 35.71%),the difference was statistical significance(P<0.05). Conclusion Through the antipsychotics agents show good the rapeutic effect on schizophrenia,but the long-term application of antipsychotic agents can lead to the increase of blood fat level and liver damage(fatty liver).The timely detection and prevention measures should be taken in schizophrenia patients with a long-term application of antipsychotic agents.