PROPANIDID VERSUS THIOPENTONE FOR INDUCTION OF GENERAL ANAESTHESIA IN ELECTIVE CAESAREAN SECTION |
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| Authors: | BARAKA, ANIS O'BRIEN, M. ASLANIAN, E. SAADE, R. |
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| Affiliation: | Department of Anesthesiology, American University of Beirut Beirut, Lebanon |
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| Abstract: | A comparison was made of the Apgar scores of ninety-four neonatesborn by elective Caesarean section. Propanidid was used to induceanaesthesia in forty women and thiopentone in fifty-four. Anaesthesiawas maintained with nitrous oxide and muscle relaxants. Theincidence of neonatal depression was higher in the thiopentonegroup than in the propanidid group, particularly when induction-deliverytime was prolonged more than 10 minutes. This is attributedto the different fates of these drugs: propanidid is rapidlyhydrolyzed by esterases, while thiopentone is very slowly metabolizedin the liver. |
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