VEGF在非小细胞肺癌(NSCLC)组织中的表达及意义

目的:研究血管内皮生长因子(VEGF)在非小细胞肺癌中的表达及其临床意义.方法:应用免疫组化(IHC)染色技术检测101例非小细胞肺癌及20例肺良性病变组织VEGF的表达水平并结合临床资料进行综合分析.结果:经χ2检验VEGF在非小细胞肺癌组织和良性病变组织中,两组对比差异具有显著性(P＜0.01).VEGF的表达与组织学类型无关(P＞0.05),VEGF表达水平与NSCLC的TNM分期呈正相关,而与NSCLC组织分化程度无关,与淋巴结转移成正相关,与原发灶大小有关,VEGF的阳性表达与术后生存时间呈负相关具有较强的侵袭和转移能力.结论:VEGF可作为预测NSCLC患者术后复发转移情况及临床预后的生物学参考指标.

Expression and significance of VEGF in non-small cell lung cancer specimens

Objective:To study the expression and significance of VEGF in non-small cell lung cancer (NSCLC) specimens.Methods:Immunohistochemical method was used to detect the expression of VEGF in101 cases of NSCLC and 20 cases of non-cancerous pulmonary disease tissue.The relationship between the biological marker and some clinicalpathological parameters was analyzed.Results:The positive rate of VEGF in NSCLC was much higher than that in the normal lung tissue(P<0.01).The expression of VEGF was not related to histopathology(P>0.05).The VEGF expression was positively correlated with TNM staging in NSCLC.The expression rate of VEGF was associated with lymph node metastasis.The VEGF expression was not related to tumor volume .The positive expression of VEGF had a negative relation to survival time after operation(P<0.01).Conclusion:The VEGF expression might play an important role in predicting tumor invasion and metastasis of human NSCLC,and.VEGF may serve as a parameter for predicting recurrence,metastasis and prognosis of lung cancinoma.