Effect of Histamine Receptor Blocking on Human Antibody-dependent Cell-mediated Cytotoxicity |
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| Authors: | I. LÁ NG,K. TÖ RÖ K,P. GERGELY,K. NÉ KÁ M,GY. PETRÁ NYI |
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| Affiliation: | Second Department of Medicine, Semmelweis University Medical School, Budapest, Hungary |
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| Abstract: | The effect of H1 and H2 receptor-blocking agents on antibody-dependent cell-mediated cytotoxicity (ADCC) was studied. The H1 receptor-blocker clemastinum and the H2 receptor blocker cimetidine dose-dependently inhibited the antibody-dependent cytotoxic activity of normal human peripheral blood mononuclear cells on chicken erythrocytes. The inhibition cannot be explained either by a direct toxic effect on effector cells or by blocking of Fc receptors. The possible involvement of histamine receptor-bearing effector cells in human ADCC is suggested. |
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