A possible relationship between catecholamines and acute toxicity of desipramine |
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| Authors: | Harbans Lal Roger M. Brown |
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| Affiliation: | (1) Department of Pharmacology, University of Kansas, Lawrence, Kansas;(2) Department of Pharmacology, University of Rhode Island, 02881 Kingston, Rhode Island, USA;(3) Department of Pharmacology, University of Chicago, Chicago, Illinois |
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| Abstract: | Summary Acute toxicity of desipramine in mice was shown to be influenced by other drugs. Pretreatment with reserpine but not with chlorpromazine, disulfiram, or p-chlorophenylalanine protected mice against desipramine toxicity. Reserpine protection was reversed by dopa or dopa and disulfiram but not by methyldopa or 5-hydroxytryptophan. These results suggested a relationship between catecholamines and desipramine toxicity. |
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