| 紫外分光光度法测定尿中氧氟沙星的排泄量 |
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| 引用本文： | 徐珽,马戎骊,樊萍,潘小鸥. 紫外分光光度法测定尿中氧氟沙星的排泄量[J]. 中国药房, 2001, 12(9): 541-542 |
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| 作者姓名： | 徐珽 马戎骊 樊萍 潘小鸥 |
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| 作者单位： | 华西医科大学附属第一医院药剂科,成都市,610041 |
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| 摘 要： | 目的：对国产氧氟沙星片药代动力学进行研究。方法：采用紫外分光光度法测定氧氟沙星尿药浓度。结果：药代动力学参数分别为：Ｋ＝０.１２７８ｈ；Ｔ１２＝５．９６ｈ；Ｘｕ０－２４＝１６５．８４ｍｇ；排泄率（Ｑ）＝８２８４％。结论：本法简便、快捷，可作为药代动力学研究和临床监测的有效方法。
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| 关 键 词： | 氧氟沙星片 紫外分光光度法 尿排泄量 |
| 文章编号： | 1001-0408(2001)09-0541-02 |
| 修稿时间： | 2001-03-21 |
Determination of Ofloxacin Excretion in Urine by UV-spectrophotometry Method |
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| XU Ting,MA Rongli,FAN Ping,PAN Xiaoou. Determination of Ofloxacin Excretion in Urine by UV-spectrophotometry Method[J]. China Pharmacy, 2001, 12(9): 541-542 |
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| Authors: | XU Ting MA Rongli FAN Ping PAN Xiaoou |
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| Abstract: | AIM: To study the pharmacokinetic characteristics of domestic ofloxacin tablet. METHODS: A method of deter- mination of drug concentration in urine by UV-spectrophotometry was established. RESULTS: K = 0. 1 278/h; T1, 2 = 5. 96h, Xu0-24 = 165. 84mg; (Q) = 82. 84%. CONCLUSION: This method is simple and rapid, it is suitable for pharmacokinetics study and clinical monitoring. |
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| Keywords: | ofloxacin UV-spectrophotometry excretion in urine |
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