Conformation and kinetic characteristics of interactions between local anesthetics and aqueous solutions of hydroxypropylmethylcellulose |
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| Authors: | A P Galenko-Yaroshevskii I A Varlashkina Kh P Takhchidi B E Malyugin A S Dukhanin |
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| Institution: | (1) Krasnodar Affiliated Department of Southern Bureau of Russian Academy of Medical Sciences, Russia;(2) S. N. Fedorov Eye Microsurgery Center, Federal Agency for Health Care and Social Development, Russia;(3) Russian State Medical University, Moscow |
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| Abstract: | Conformation and kinetic characteristics of the interactions of local anesthetics lidocaine (xycaine), tetracaine (dicaine),
bupivacaine, and new RU-1117 compound with proven anesthetic activity with Visiton (1% hydroxypropylmethylcellulose in phosphate
buffer) were studied. It was found that complex formation between the local anesthetics and hydroxypropylmethylcellulose is
a time-dependent reversible process. The equilibrium is attained within 2.5–8.0 h and depends on the chemical nature of local
anesthetic.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 143, No. 5, pp. 563–567, May, 2007 |
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| Keywords: | hydroxypropylmethylcellulose local anesthetics interaction kinetics |
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