游离DNA与临床肿瘤的研究进展

游离DNA是一种存在于血浆或血清、脑脊液及滑膜液等体液中的细胞外DNA。体液中游离DNA水平和(或)基因的改变与疾病的发生发展有密切的关系。作为一种新型的检测对象,游离DNA取材简便,更适合于临床疾病的研究应用。游离DNA在临床肿瘤中的研究应用广泛,研究发现游离DNA的改变与肿瘤的发生发展密切相关。

Research Progress of Circulating DNA and Clinical Tumor

Circulating DNA is a free DNA in humoral fluid including plasma, serum, cerebrospinal fluid and synovial fluid. The change in circulating DNA level and (or) gene is associated with the occurrence and development of some disorders. As a new object of testing, circulating DNA is convenient for clinical use due to its accessibility. Circulating DNA has a wide use in clinical oncological research. Some studies have shown that the alteration in circulating DNA is directly associated with the occurrence and development of tumor.