无先兆偏头痛患者血单胺类递质变化的研究

目的 了解5－羟色胺（5－TH）、5－羟吲哚乙酸（5－HIAA）、多巴胺（DA）、去甲肾上腺素（NE）在无先兆偏头痛发病中的作用。方法 用荧光分光光度法检测35例无先兆偏头痛患者（发作期16例、间歇期19例）和23例正常人血浆及血小板5－HT、5－HIAA、DA、NE含量。结果 无先兆偏头痛患者发作期组血浆5－HT含量低于对照组（P＜0.05),而5－HIAA含量高于对照组（P＜0.01）；间歇期组5－HT含量高于发作期组，而5－HIAA含量低于发作期组（P＜0.01）；发作期组血浆DA、NE含量均低于对照组（P＜0.01）间歇期组血浆DA与发作期组相比亦有显著性差异（P＜0.01）。无先兆偏头痛患者发作期组血小板5－HT含量高于对照组和间歇期组，而5－HIAA含量低于对照组和间歇期组（P＜0.01）；而发作期组血小板NE含量高于对照组和间歇期组（P＜0.01）；DA含量则低于对照组和间歇期组（P＜0.01）。结论 单胺类递质对偏头痛的发生可能有重要意义。

The changes of contents of blood monoamine transmitters in migraineurs without aura

Objective To study the changes of 5-HT、 5-HIAA、 DA and NE in theplasma and platelets of migraineurs without aura. Methods The 5-HT、 5-HIAA、 DA and NE in the plasma and platelet of migraineurs without ura both interictally and ictally (16 patients in ictally and 19 patients in interictally) were measured with 23 age-matched control subjects. Results In the attack stage of migraineurs without aura, the contents of plasma 5-HT, DA and NE were lower than the normal control groups, while the content of 5-HIAA was markedly higher than the control. The contents of plasma 5-HT and DA were markedly lower than the headache-free group, the content of plasma 5-HIAA was higher than the headache-free group. And in the attack stage, the contents of platelet 5-HT and NE were markedly higher than the control and the headache-free groups, while the contents of platelet 5-HIAA and DA were lowers than the control and the headache-free group. Conclusion The changes of the concentrations of Monoamine Transmitters in migraineurs' plasma and platelet might play and important role in developing the migraine without aura.