不同分子量的聚乙烯醇载药膜片体外溶出度测定

 采用可见紫外分光光度法对不同聚合度及质量比的聚乙烯醇（ＰＶＡ）制成的含有硫酸阿托品及甲硝唑载药膜，在不同溶出介质中的溶出度进行测定、比较，为制备ＰＶＡ缓释载药膜片，选择适宜的质量比及相应的聚合度，提供参考依据。

Determination of the drug extracorporeal dissolvability of medicatedPVA film with different molecular weight

We determined the drug dissolvability of atropine sulfate and metronidazole carry-ing polyvinye alcohol(PVA)films。 With different degree polymerization and mixture ratio in vari-ous dissolving mediums by using UV/VIS spectrophotometry approach. The data on appropriatemass ratio and degree polymerization of the PVA are useful in preparing sustained drug slow re-leasing PVA films。