A Randomised,Double-Blind,Placebo-Controlled Crossover Trial of Resveratrol Supplementation for Prophylaxis of Hormonal Migraine |
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Authors: | Jemima S. A. Dzator Peter R. C. Howe Kirsten G. Coupland Rachel H. X. Wong |
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Affiliation: | 1.School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan 2308, Australia; (J.S.A.D.); (K.G.C.); (R.H.X.W.);2.Adelaide Medical School, University of Adelaide, Adelaide 5005, Australia;3.Centre for Health Research, University of Southern Queensland, Raceview 4305, Australia;4.Hunter Medical Research Institute, New Lambton Heights 2305, Australia |
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Abstract: | Resveratrol, a vasoactive phytoestrogen, has beneficial effects on cerebrovascular function. Previous research has shown that hormonal migraineurs have poorer cerebrovascular function than non-migraineur women. We aimed to investigate if resveratrol supplementation for three months could reduce the hormonal migraine burden index (HMBI: the number of days with menstrual migraine per month), reduce migraine-related disability and improve migraine-related quality of life. A randomised, double-blind, placebo-controlled, crossover, intervention trial was conducted in 62 hormonal migraineurs (mean age: 37.5 ± 0.8 years). Participants consumed 75 mg of resveratrol or matching placebo capsules twice daily for three months before crossing over to the other treatment arm. Participants completed a daily diary and the Headache Impact Test-6™, Migraine Disability Assessment and Migraine-Specific Quality of Life questionnaires at months 0, 3 and 6. The HMBI was the primary outcome and was calculated using data extracted from the participant’s diary. No differences in the HMBI (p = 0.895), the Headache Impact Test-6™, the Migraine Disability Assessment and Migraine-Specific Quality of Life were found between the resveratrol and placebo treatments. Resveratrol supplementation for three months did not affect the HMBI, the migraine-related disability or quality of life measures in our cohort of hormonal migraineurs. |
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Keywords: | resveratrol phytoestrogen nutrient intervention cerebrovascular function hormonal migraine prophylaxis migraine disability assessment |
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