既往健康成人巨细胞病毒性重型肝炎的临床分析

目的 :分析巨细胞病毒性重型肝炎的临床特点。方法 :采用酶联免疫吸附实验及聚合酶链反应对 5例巨细胞病毒性重型肝炎的病原学进行检测 ,定期检测其肝功能、三大常规、凝血酶原时间、肝脏B超等 ,同时观察临床症状、体征的变化。结果 :5例巨细胞病毒性重型肝炎的临床表现特点为急性起病、发热、黄疸进行性加深和严重的肝功能损害 ,在病程 3～ 4周时 ,病情急剧变化 ,预后极差。结论 :巨细胞病毒也是病毒性肝炎的致病因子之一 ,既往健康成人出现原因不明的重型肝炎时应高度警惕本病

A Clinical Analysis of Cytomegalovirus Fulminant Hepatitis in Previously Healthy Adults

Objective:To analyze the clinical features of fulminant CMV hepatitis. Methods:Five cases of fulminant CMV hepatitis in previously healthy adults were etiologically detected by using enzyme linked immunosorbent assay (ELISA) and polymerase chain reaction (PCR). Their blood, urine and stool were analysed and the liver function and prothrombin time tested.The liver ultrasonic examination was performed at intervals,and their signs and symptoms were observed continuously. Results: Fulminant CMV hepatitis was acute, outbreaking and charaterized by persistent fever, rapidly increasing jaundice and severely damaged liver function. At the third to fourth week of its course, pathogenetic condition was rapidly aggravated. Its prognosis was badly poor. Conclusion: Cytomegalovirus is one of the factors leading to hepatitis. When a previously healthy adult suffers from fulminant hepatitis with unclear pathogen, cytomegalovirus infection should be considered.