| 山梨酸对呋喃西林溶液稳定性的影响 |
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| 引用本文： | 刘金来,张秀华,黄学荪.山梨酸对呋喃西林溶液稳定性的影响[J].中国药业,2005,14(7):27-28. |
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| 作者姓名： | 刘金来 张秀华 黄学荪 |
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| 作者单位： | 1. 浙江省温州市第三人民医院,浙江,温州,325000
2. 温州医学院第一附属医院,浙江,温州,325000 |
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| 摘 要： | 目的:考察呋喃西林溶液中加入山梨酸对其稳定性的影响.方法:用反相高效液相色谱法测定呋喃西林溶液含量,通过初均速法对呋喃西林溶液作稳定性试验,并与留样观察作对照.用微生物限度检查法测定其防腐能力.结果:在改变防腐剂的条件时,既可提高其化学稳定性,又能提高该制剂的防腐能力.结论:加入山梨酸能明显提高呋喃西林溶液稳定性.
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| 关 键 词： | 呋喃西林 山梨酸 苯甲酸钠 反相高效液相色谱法 稳定性 |
| 文章编号： | 1006-4931(2005)07-0027-01 |
| 修稿时间： | 2004年12月22 |
Effect of Sorbic Acid on the Stability of Furacilin Solution |
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| Liu Jinlai,Zhang Xiuhua,HUANG Xuesun.Effect of Sorbic Acid on the Stability of Furacilin Solution[J].China Pharmaceuticals,2005,14(7):27-28. |
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| Authors: | Liu Jinlai Zhang Xiuhua HUANG Xuesun |
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| Abstract: | Objective:To study the stability of furacilin solution with sorbic acid .Methods:The concentration of furacilin solution was deter-mined with RP-HPLC.In itial average rate method was applied to test the stability of furacilin solutio n which was compared with samples reserved for observing.The ability of preserva tion from decay was test by microbial limit.Results:Furacilin solution with sorb ic acid was more stable than control and the preservation from decay was more st rong than the control.Conclusion:It is very good for the stability of furacilin solution with sorbic acid. |
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| Keywords: | sorbic acid furacilin sodium benzoate RP-HPLC stability |
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