2/100Hz电刺激可降低脱毒期美沙酮用量和脱毒后近期抑郁及焦虑情绪

目的··:了解2/100Hz跨皮肤电刺激对海洛因依赖者脱毒期的美沙酮临床用量和脱毒后近期抑郁、焦虑情绪的影响。方法··:A组采用单纯美沙酮14d替代递减疗法 ;B组使用2/100Hz跨皮肤电刺激辅助小剂量美沙酮,连续治疗14d。治疗后 ,比较两组美沙酮的剂量差别 ,评定病人治疗前后的抑郁和焦虑程度。结果·· :(1)B组每人使用美沙酮的平均总剂量明显低于A组 ,两组之间存在着极显著性差异 (P<0.001) ;(2)B组抑郁和焦虑情绪在治疗后明显低于治疗前 (P<0.001) ,也低于A组治疗后 (P<0.001)。结论··:2/100Hz跨皮肤电刺激可使脱毒期的美沙酮的临床用量降低约75 % ;明显缓解脱毒者在脱毒后近期的抑郁和焦虑情绪

REDUCTION OF METHADONE DOSAGE AND RELIEF OF DEPRESSION AND ANXIETY BY 2/100 HzTENS FOR HEROIN DETOXIFICATION

Objective: To observe if 2/100 Hz transcutaneous electrical nerve stimulation (TENS) produced by Han's acupoint nerve stimulator (HANS)will reduce methadone (MTD) dose, relieve anxiety and depression of heroin addicts during and after detoxification. Method: The patients were randomly divided into Group A(n=14)and Group B(n=23). Group A was treated with MDT only, group B received HANS plus MTD. Hamilton Depression Scale and Hamilton Anxiety Scale were used to measure the degree of depression and anxiety of the addicts before and after treatment. Result: (1) The average dose of MTD used by Group A in 14-day detoxification period was 202 mg±s 70 mg, whereas Group B was only 51.50 mg±s 31.00 mg, a reduction of 75% (P<0.001); (2) The score of depression and anxiety of Group A remained at the same level after MTD treatment, whereas in Group B, there was a 40% and 33% reduction in depression and anxiety, respectively (P<0.001). Conclusion: The use of HANS reduces MTD dosage, and ameliorates the degree of depression and anxiety of heroin addicts during and after detoxification.