新生儿正常甲状腺病态综合征

新生儿正常甲状腺病态综合征或非甲状腺疾病综合征(NTIS)是由于非甲状腺的全身性疾病引起的甲状腺功能(甲功)检查上异常的疾病。NTIS的甲功异常包括:低T3综合征、低T3低T4综合征、高T4综合征以及其他异常。甲功异常的影响因素有:早产、缺氧、感染、营养、母亲疾病等。T3T4的下降将影响脑细胞的生长和分化并加速小脑细胞程序化死亡。对原发疾病治疗恢复期,甲功仍然不能恢复者,给予适当的甲状腺激素替代治疗,可改善神经系统症状,促进病情恢复及减少后遗症的发生。

The Normal Thyroidal Sick SyndromeIn Neonate

The normal thyroidal sick syndrome or nonthyroidal illness syndrome(NTIS) of neonate is the disease of abnormal thyroidal function by systemic diseases except of thyroid.Abnormalities in thyroidal function of NTIS include low T_3 syndrom,low T_3 and low T_4 syndrom,high T_4 syndrom and others.There are many influencing factors in abnormality of thyroidal function,such as premature,hypoxia,infection,nutrition,diseases of mother,ect.The decrease of T_3 and T_4 will affect the growth and differentiation of brain cell and will accelerate programmed death of cerebellar cell.If the thyroidal function can′t recover in the treatment convalescence period of primary disease,the substitution therapy of proper thyroid hormone will improve the symptom of neural system,promote recovery of disease and minimize the sequelae.