胃内灌注盐酸对胃粘膜血流量和胃损伤的影响

应用氢气清除法测定胃粘膜血流量（ｇａｓｔｒｉｃｍｕｃｏｓａｌｂｌｏｏｄｆｌｏｗ，ＧＭＢＦ），观察ＧＭＢＦ与胃粘膜适应性细胞保护作用的关系。结果显示：单纯胃内灌注０．１５ｍｏｌ／ＬＨＣＩ＋１５％乙醇或０．６ｍｏｌ／ＬＨＣＩ＋１５％乙醇，造成胃粘膜不同程度的损害，同时ＧＭＢＦ增加，动脉压没有明显改变；预先用０．１５ｍｏｌ／ＬＨＣＩ＋１５％乙醇胃内灌注可使随后用０．６ｍｏｌ／ＬＨＣｌ＋１５％乙醇引起的ＧＭＢＦ继续增加，而胃粘膜损害明显减轻。实验结果提示，弱刺激引起的胃粘膜血流增多是胃粘膜适应性细胞保护的一个重要因素。

EFFECT OF GASTRIC PERFUSION WITH HCI ON GASTRIC MUCOSL BLOOD FLOW AND GASTRIC LESION

The relation between gastric mucosal blood flow (GMBF) and adaptive cytoprotection was studied in rats, with hydrogen gas clearance used to measure the GMBF, Perfusion of the rat stomach with either 0.15mol/L HCI plus 15%ethanol 0r 0.6 mol/LHCI plus 15%ethanol led to marked increase of GMBF and significantly different degrees of gastric mucosal damage proportional to the respective concentrations of the irritant (HCI),but the arterial blood pressure was not altered. When the strong irritant (0.6 mol/LHCI in alcohol) was perfused into the rat stomach which had been pretreated with mild irritant (0.15 mol/LHCI in alc0hol), the GMBF was further increased but the mucosal damage was significantly mitigated, i.e. less serious than that caused by the strong irritant alone. These results show that the increase of GMBF caused by a mild irritant is an important factor in adaptive gastric protection.