Morphological manifestations of hereditary hypertrophic cardiomyopathy in W/SSM rats |
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| Authors: | R. I. Salganik N. A. Solov'eva L. M. Nepomnyashchikh D. E. Semenov |
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| Affiliation: | (1) Department of Molecular Genetics, Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk;(2) Laboratory of General Pathological Anatomy, Research Institute of Regional Pathology and Pathomorphology, Seberian Division of the Russian Academy of Medical Sciences, Novosibirsk |
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| Abstract: | A W/SSM strain of rats with hereditary hypertrophic cardiomyopathy has been created by inbreeding Wistar rats selected for an increased, sensitivity to the cataractogenic effect of high doses of galactose. It is shown that myocardial hypertrophy attended by a diffuse stroma collagenization, focal sclerotic changes, and signs of, chronic heart failure spontaneously develops in these animals. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 118, N o 8, pp. 203–207, August, 1994 |
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| Keywords: | W/SSM rats hereditary hypertrophic cardiomyopathy myocardium cardiomyocyte count |
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