Tailored strategy for AML patients receiving allogeneic peripheral blood stem cell transplantation |
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Authors: | Sohn Sang Kyun Kim Jong Gwang Kim Dong Hwan |
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Affiliation: | Department of Hematology/Oncology, Kyungpook National University Hospital, Daegu, Korea. ksohn@knu.ac.kr |
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Abstract: | Considering the heterogeneity of acute myelogenous leukemia (AML), along with the pros and cons of allogeneic peripheral blood stem cell transplantation (PBSCT), a tailored strategy is needed to minimize the transplant-related mortality and maximize the transplant outcomes in AML patients exhibiting certain factors that have an impact on the post-transplant quality of life and outcomes. The factors that need to be considered when tailoring a strategy in an allogeneic PBSCT setting include the recipient's performance status and co-morbid disease include AML risk stratification, disease status, expected severity of graft-versus-host disease, and the necessity of a graft-versus-leukemia effect. Accordingly, this review article describes a possible tailoring strategy for AML patients receiving allogeneic PBSCT based on certain factors influencing the transplant outcome. |
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Keywords: | allogeneic peripheral blood stem cell transplantation AML tailored strategy |
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