Primary squamous cell carcinoma of the breast after cured Hodgkin's disease |
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| Authors: | Katsumasa Kuroi Akihiko Osaki Hirohumi Yamada Masakazu Toi Tetsuya Toge Yasuo Takimoto Atushi Kuramoto Koji Arihiro Kouki Inai |
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| Affiliation: | (1) The Department of Surgery Research Institute for Nuclear Medicine and Biology, Hiroshima University, Japan;(2) The Department of Internal Medicine, Research Institute for Nuclear Medicine and Biology, Hiroshima University, Japan;(3) the 2nd Department of Pathology, Hiroshima University School of Medicine, Kasumi 1-2-3, Minami-ku, 734 Hiroshima, Japan |
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| Abstract: | An unusual case of primary squamous cell carcinoma of the breast occurring after cured Hodgkin's disease is reported herein. A 27-year-old woman developed a left breast mass 2 years after chemotherapy and radiation for nodular sclerosing stage IIB Hodgkin's disease. Excisional biopsy revealed squamous cell carcinoma of the breast and a modified radical mastectomy was performed, however, no metastasis was found in the axillary nodes. She received etoposide, mitomycin-C, and doxifluoridine as adjuvant chemotherapy, and remains well without any evidence of recurrent Hodgkin's disease or breast cancer. To our knowledge, this is the first reported case of primary squamous cell carcinoma of the breast associated with Hodgkin's disease. The risk of patients treated for Hodgkin's disease developing breast cancer as a second malignant neoplasm is discussed following the report of this case. |
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| Keywords: | breast cancer squamous cell carcinoma Hodgkin's disease double cancer |
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