Determination of meta- and para-hydroxyphenylacetic acid levels in single caudate nuclei by selected metastable peak monitoring: a new sensitive gas chromatographic-mass spectrometric procedure |
| |
| Authors: | D.A. Durden |
| |
| Affiliation: | Psychiatric Research Division, University Hospital, Saskatoon, Sask. S7N 0X0 Canada |
| |
| Abstract: | The levels of meta- and para-hydroxyphenylacetic acids in rat brain caudate nuclei have been determined by a new gas chromatography-mass spectrometric (GC-MS) procedure in which metastable transitions specific to the derivatized acids are observed. The method is more sensitive than previous procedures and allows determination of the acid concentrations using single caudate nuclei. The levels of the meta- and para-isomers were found to be 9.2 ± 1.5 and 43 ± 3.7 ng/g, respectively. |
| |
| Keywords: | biogenic amines gas chromatography-mass spectrometry metastable peak monitoring mass spectrometry caudate nucleus metabolites |
| 本文献已被 ScienceDirect 等数据库收录！ |
