The effect of cimetidine on immunological parameters in Crohn's disease: A double blind trial |
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Authors: | J. Hamid I.N. Ross C. Ward |
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Affiliation: | Departments of Medicine and Surgery, Hope Hospital (University of Manchester School of Medicine), Eccles Old Road, Salford M6 8HD, U.K. |
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Abstract: | Thirty-six patients with Crohn's disease were entered into a double-blind trial to assess any beneficial effect that cimetidine might have on immunological and clinical status. Eighteen patients were randomized to receive cimetidine, 1 g orally for 28 days, and the other 18 patients to receive a placebo. There was no alteration in clinical status in the cimetidine-treated group. Although 64% of the patients were anergic, augmentation of skin tests to candida, mumps, tuberculin, streptokinase/streptodornase and trichophyton antigens, was not observed in the cimetidine-treated patients. The patients with Crohn's disease, as a whole had higher absolute numbers of suppressor T-lymphocytes, 0.70 × 109/litre (0.21?2.36, n = 35) compared to control values, 0.5 × 109/litre (0.16–1.55, n = 25) (P < 0.05). However, there was no significant difference in proportions of suppressor and helper T-lymphocytes, lymphocyte activation and humoral immunity after cimetidine treatment. The lack of any clear modulation of immunity by cimetidine, would be against trying H2 antagonists in a long term clinical trial. |
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Keywords: | cimetidine Crohn's disease skin test antigens T-subpopulations |
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