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Normal bone marrow karyotype in paroxysmal nocturnal hemoglobinuria—A cooperative European study
Authors:A Zaccaria  D Barbieri  GL Castoldi  P Ferraresi  C Finelli  DK Hossfeld  F Mitelman  G Rosti  N Testoni  H Van Den Berghe
Institution:1. Institute of Hematology “L. e A. Seràgnoli” University of Bologna, Italy;2. Chair of Hematology, University of Ferrara, Italy;3. Department of Oncology and Hematology, University of Hamburg, Federal Republic of Germany;4. Department of Clinical Genetics, University of Lund, Sweden;5. Academisch Ziechenhuis, Saint Raphael, University of Leuven, Belgium
Abstract:Sixteen patients with paroxysmal nocturnal hemoglobinuria (PNH) from five European centers have been submitted to chromosome analysis. All of them had a normal bone marrow karyotype. The associations between some chromosomally abnormal cases reported in the literature and “typical” PNH or PNH phenomenon during the course of other hematological disorders are discussed.
Keywords:Address requests for reprints to Alfonso Zaccaria  M  D    Istituto di Ematolgia “L  e A  Seràgnoli” Policlinico S  Orsola  Via Massarenti  9  40138 Bologna  Italy  
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