| 多相脂质体139注射液化学稳定性的研究 |
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| 引用本文： | 邓英杰,苏德森,李焕秋,顾学裘.多相脂质体139注射液化学稳定性的研究[J].沈阳药科大学学报,1985(3). |
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| 作者姓名： | 邓英杰 苏德森 李焕秋 顾学裘 |
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| 作者单位： | 沈阳药学院制剂研究室，沈阳药学院制剂研究室，沈阳药学院制剂研究室，沈阳药学院制剂研究室 |
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| 摘 要： | 本文根据多相脂质体139注射液的处方组成及其主要有效成份的结构和性质,设计了利用碘量法测定139注射液中不饱和度(双键氧化)和电导滴定法测定酸度的变化规律,得出包封于脂质体中药物的氧化反应符合零级反应速度方程,载体主要成分的脂键水解反应也符合零级反应速度方程;并求得了多相脂质体139注射液中双键氧化反应与载体成分的水解反应的活化能和反应速度常数;预测了药物贮存期 t_(0.9)~(25℃)=2.63年。同时,本文提出了利用电导滴定曲线确定在缓冲溶液及多种化学成份的复杂体系中弱酸盐滴定终点的新方法。
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| 关 键 词： | 多相脂质体 139注射液 化学稳定性 电导滴定 |
STUDIES ON THE CHEMICAL STABILITY OF THE INTRAVENOUS INJECTION OF POLYPHASE LIPOSOME(139)IN THE FORM OF SUSPENSION |
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| Deng Yingjie Li Huanqiu Su Desen Gu Xueqiu.STUDIES ON THE CHEMICAL STABILITY OF THE INTRAVENOUS INJECTION OF POLYPHASE LIPOSOME(139)IN THE FORM OF SUSPENSION[J].Journal of Shenyang Pharmaceutical University,1985(3). |
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| Authors: | Deng Yingjie Li Huanqiu Su Desen Gu Xueqiu |
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| Institution: | Koo Hsuehchiu |
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| Abstract: | On the basis of previous seven reports,the present paper describes further the tests on the chemical stability of Polyphase Lrposome 139 for Intravenous Injection in the form of suspension.Using two methods,iodimetry and the con- ductimetric titration the following conclusion was drawn,the effective time of the injection(139)is for t_(0.9)=2.63 years.In this paper also is reported a new way,which could show the titration end point of the salts of weak acids by a conductimetric titration curve in a buffer solution containing several chemical constituents. |
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| Keywords: | Polyphase liposome Injection 139 Chemical stability Conductimetric titration |
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