来氟米特联合甲氨蝶呤治疗类风湿关节炎的疗效评价

目的：评价来氟米特联合甲氨蝶呤对类风湿关节炎的治疗效果和安全性。方法：选取2014年3月～2015年12月于我院风湿免疫科就诊的类风湿关节炎患者100例，随机均分为联合组和单纯组，联合组接受来氟米特合甲氨蝶呤治疗，单纯组只接受甲氨蝶呤单独治疗；治疗结束后比较两组临床症状改善情况，血沉、炎症相关因子改变指标等，并分析联合用药的安全性。结果：联合组临床症状和血清学指标改善情况均较单纯组明显（P＜0.05），药物副反应两组无明显差异（P﹥0.05）。结论：联合运用来氟米特和甲氨蝶呤治疗类风湿关节炎疗效确切安全性高，临床应用时结合患者的疾病状况使用。

The clinical efficacy of leflunomide combined with methotrexate in Rheumatoid arthritis

Objective:To evaluate the clinical efficacy and safety of leflunomide combined with methotrexate in rheumatoid arthritis. Methods:100 rheumatoid arthritis patients were collected,randomize into single group and combined group, both received methotrexate treat, while on this basis, combined group received methotrexate treat; the clinical symptoms improvement, ESR, inflammation-related factors were compared after treat, analyzed the security of combination therapy. Results:The clinical symptoms improvement and serology improved significantly in the combined group than single group (P<0.05);there was no difference in the adverse drug reactions (P﹥0.05). Conclusion:Leflunomide and methotrexate combination therapy in rheumatoid arthritis is effective, combine with the disease condition of the patient to medicate.