| p27和p53在乳腺癌中的表达及意义 |
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| 引用本文： | 陶然,李厚祥,李鹏,芮理.p27和p53在乳腺癌中的表达及意义[J].江苏医药,2006,32(3):230-231. |
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| 作者姓名： | 陶然 李厚祥 李鹏 芮理 |
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| 作者单位： | 226001,南通大学附属医院普外科 |
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| 摘 要： | 目的研究p27和p53在乳腺癌表达的意义。方法以免疫组化法分别检测56例乳腺癌和36例乳腺良性肿瘤患者p27及p53的表达水平。结果（1）p27和p53均与乳腺癌的TNM分期相关。p27的表达水平还与p53相关。（2）生存率的比较分析结果，p27高表达组5年无病生存率为91．9％，明显优于低表达组（42．1％）（P〈0．01），p53高表达组5年无病生存率为61．3％，明显低于低表达组（92．0％）（P〈0．01）。结论检测p27和p53对乳腺癌的预后有重要价值。
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| 关 键 词： | 乳腺癌 预后 |
| 收稿时间： | 2005-05-16 |
| 修稿时间： | 2005年5月16日 |
Expression and significance of p27 and p53 in breast cancer |
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| TAO Ran, LI Houxiang, LI Peng, et al.Expression and significance of p27 and p53 in breast cancer[J].Jiangsu Medical Journal,2006,32(3):230-231. |
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| Authors: | TAO Ran LI Houxiang LI Peng |
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| Institution: | Department of General Surgery, Affiliated Hospital, Nantong University, Nantong 226001, CHINA |
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| Abstract: | Objective To study the significance of p27 and p53 expression in patients with breast cancer.Methods p27 and p53 were determined immunohistochemically from 56 patients with breast cancer and 36 patients with benign mammary tumors.Results(1) Both p27 and p53 were correlated with TNM stage.The expression of p27 was also correlated with that of p53.(2) Univariat(analysis) demonstrated that disease-free survival rate in patients with higher p27 expression was 91.9%,which was significantly higher than that in those with lower expression(42.1%).The survial rate in patients with p53 overexpression was 61.3%,which was markadly lower than that in those with low p53 expression.Conclusion Detection of the expressions of p27 and p53 has an important significance in predicting the prognosis of breast cancer. |
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| Keywords: | p27 p53 |
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