| 苦参制剂对体外血清胆碱酯酶和转氨酶活性的影响 |
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| 引用本文： | 聂红明,金树根,李运东,高月求,陈建杰,王灵台. 苦参制剂对体外血清胆碱酯酶和转氨酶活性的影响[J]. 上海中医药杂志, 2009, 43(4): 67-69 |
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| 作者姓名： | 聂红明 金树根 李运东 高月求 陈建杰 王灵台 |
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| 作者单位： | 上海中医药大学附属曙光医院肝炎科,上海,201203 |
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| 基金项目： | 上海市卫生局资助项目 |
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| 摘 要： | 目的探讨临床常用苦参制剂（肝炎灵、苦参碱和苦参素）对血清胆碱酯酶和转氨酶活性的影响。方法采用体外药物与血清共育方式，分别于药物与血清共育10min和24h后，用全自动生化分析仪检测血清胆碱酯酶和转氨酶的活性。结果只有苦参碱对血清胆碱酯酶和转氨酶活性有直接抑制作用，苦参素和肝炎灵对血清胆碱酯酶和转氨酶活性均无直接抑制作用。结论苦参碱能直接抑制血清胆碱酯酶和转氨酶活性；肝炎灵和苦参素对体外血清胆碱酯酶和转氨酶活性无直接抑制作用，其体内用药致血清胆碱酯酶活性下降的原因是其在体内经过代谢转化成为苦参碱或其他具有强力抑制胆碱酯酶活性的代谢产物或转化产物。
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| 关 键 词： | 苦参碱 肝炎灵 苦参素 胆碱酯酶 转氨酶 |
Effects of Sophora Flavescens Preparations on in vitro Serum Cholinesterase and Transaminase Activities |
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| NIE Hong-ming JIN Shu-gen LI Yun-dong GAO Yue-qiu CHEN Jian-jie WANG Ling-tai Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine. Effects of Sophora Flavescens Preparations on in vitro Serum Cholinesterase and Transaminase Activities[J]. Shanghai Journal of Traditional Chinese Medicine, 2009, 43(4): 67-69 |
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| Authors: | NIE Hong-ming JIN Shu-gen LI Yun-dong GAO Yue-qiu CHEN Jian-jie WANG Ling-tai Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine |
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| Affiliation: | (Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine) |
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| Abstract: | Objective To study the effects of Sophora flavescens preparations(including hepatitis tablet,matrine and kurarinone) on in vitro serum cholinesterase and transaminase activities. Methods These preparations were inocubated in hepatitis serum for 10 minutes or 24 hours; and the serum cholinesterase and transaminase activities were detected. Results Matrine could directly inhibit the cholinesterase and transaminase activities,while hepatitis tablet and kurarinone could not directly inhibit the cholinesterase a... |
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| Keywords: | Matrine hepatitis tablet kurarinone cholinesterase transaminase |
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