| 喉乳头状瘤HPV16/18感染与p53蛋白表达的相关性 |
| |
| 引用本文： | 褚汉启,E Reyt. 喉乳头状瘤HPV16/18感染与p53蛋白表达的相关性[J]. 临床耳鼻咽喉头颈外科杂志, 2000, 14(6): 271-272 |
| |
| 作者姓名： | 褚汉启 E Reyt |
| |
| 作者单位： | 1. 同济医科大学附属同济医院耳鼻咽喉科教研室,武汉,430030
2. ORL,Grenoble University Hospital,La Tronche,France |
| |
| 摘 要： | 目的：了解喉乳头状瘤组织内ＨＰＶ１６／１８的感染与抑癌基因ｐ５３变异的关系，以及ＨＰＶ感染在喉乳头状瘤发病中的作用。方法：采用ＰＣＲ和免疫组化技术，检测３５例喉乳头状瘤组织中ＨＰＶ１６／１８ＤＮＡ及ｐ５３蛋白的表达。结果：２４例组织中检出ＨＰＶ１６／１８ＤＮＡ（６８．６％）；１９例ｐ５３蛋白呈过度表达（５４．３％）；在１２例中同时检出ＨＰＶ１６／１８ＤＮＡ和ｐ５３蛋白过度表达（３４．３％）。结论：
|
| 关 键 词： | 乳头状瘤病毒 喉肿瘤 乳头肿瘤 p53蛋白 |
Study on the association between HPV16/18 and expression of p53 protein in laryngeal papillomas |
| |
| CHU Han-qi,E Reyt. Study on the association between HPV16/18 and expression of p53 protein in laryngeal papillomas[J]. Journal of clinical otorhinolaryngology, head, and neck surgery, 2000, 14(6): 271-272 |
| |
| Authors: | CHU Han-qi E Reyt |
| |
| Affiliation: | Department of Otolaryngology, Tongji Hospital, Tongji Medical University, Wuhan 430030. |
| |
| Abstract: | OBJECTIVE: To understand the relationship between the expression of p53 protein and HPV16/18 infection in laryngeal papillomas. METHOD: Using PCR and immunohistochemistry techniques examined the paraffin embedded tissues of 35 cases of laryngeal papillomas. RESULT: Showed that HPV16/18-DNA were found in 24 cases of laryngeal papillomas (68.8%); overexpression of p53 protein were detected in 19 cases (54.3%); both of HPV16/18-DNA and overexpression of p53 protein were demonstrated in 12 cases of laryngeal papillomas (34.3%). CONCLUSION: This study suggests that HPV16/18 infection and p53 gene mutation are associated with pathogenesis of laryngeal papillomas. The relation between HPV infection and p53 mutation in tissues of laryngeal papillomas remains to be clarified. |
| |
| Keywords: | |
| 本文献已被 维普 万方数据 等数据库收录！ |
