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Obstructive jaundice leads to accumulation of oxidized low density lipoprotein in human liver tissue |
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| Authors: | Comert Mustafa Ustundag Yucel Tekin Ishak Ozel Gun Banu Dogan Barut Figen |
| Affiliation: | 1. Department of Surgery, School of Medicine,Zonguldak Karaelmas University, Turkey 2. Department of Gastroenterology, School of Medicine, Zonguldak Karaelmas University, Kozlu-Zonguldak,Turkey 3. Department of Immunology, School of Medicine, Zonguldak Karaelmas University, Kozlu-Zonguldak,Turkey 4. Department of Pathology,School of Medicine, Zonguldak Karaelmas University, Kozlu Zonguldak, Turkey |
| Abstract: | Oxidized low density lipoprotein (ox-LDL) molecule is one of the most important modified lipoproteins produced during the oxidative stress. Modified lipoproteins have been defined as being part of the immune inflammatory mechanisms in association with oxidant stress. We have reported the accumulation of ox-LDL in Balb/c mice liver after bile duct ligation previously. Here, we investigated this finding in human beings with obstructive jaundice. Our study demonstrates that obstructive jaundice results in tremendous accumulation of ox-LDL in the liver tissue of patients. |
| Keywords: | Obstructive jaundice Liver Oxidative stress Oxidized low density lipoprotein |
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