基于肠道菌群理论应用中医药干预高血压研究进展

肠道菌群的菌群丰富度、益生菌数量、短链脂肪酸(Short chain fatty acids,SCFAs)的改变和肠道屏障功能等与高血压的发生密切相关.肠道菌群和血压水平的关系主要体现在以下几个方面:①高血压患者肠道菌群丰富度明显低于正常成人,且血压指数与肠道菌群中的某些细菌(主要是厚壁菌门)的数量呈正相关.②肠道菌群...

Research Progress on Intervention of Hypertension with Chinese Medicinals Based on Intestinal Flora Theory

The abundance of intestinal flora,the number of probiotics,the changes of short chain fatty acids(SCFAs)and intestinal barrier function,etc.are closely related to the occurrence of hypertension.The relationship between intestinal flora and blood pressure level is mainly reflected in the following aspects:First,the richness of intestinal flora in patients with hypertension is significantly lower than that in normal adults,and the blood pressure index is positively correlated with the number of some bacteria(mainly Firmicutes)in intestinal flora.Second,the number of most probiotics in the intestinal flora is negatively correlated with the blood pressure index.Increasing the number of probiotics within a certain range can reduce the blood pressure level.Third,SCFAs,the metabolite of intestinal flora,can inhibit inflammatory response,especially acetic acid and butyric acid,which can reduce blood pressure and improve cardiac function.Fourth,when the intestinal barrier is complete,the permeability of intestinal wall is low,which can block pathogens and inflammatory stimulation,reduce the damage of inflammation to intestinal blood vessels to a certain extent,and then give play to the potential of reducing blood pressure.At present,there are still few studies on the application of Chinese medicinals in the treatment of hypertension based on the theory of intestinal flora,especially the related studies of Chinese medicinals compounds are limited.In future research,based on the correlation between intestinal flora and hypertension,we can further explore the correlation between Gastrodia and Uncaria Decoction,Pinellia,White Atractylodes and Gastrodia Decoction and other classic formulas for the treatment of hypertension and intestinal flora,so as to provide direction for the clinical application of Chinese medicinals and the research and development of new drugs.