基于Meta分析的复方丹参注射液辅助治疗肾病综合征的系统评价

目的:系统评价复方丹参注射液辅助治疗肾病综合征的疗效与安全性.方法:检索万方、维普、中国知网、CBM、百度学术、PubMed、The Cochrane Library、EMbase等数据库,时间自建库至2020年5月.依据文献的纳入及排除标准检索所需文献,并进行方法质量评价,运用软件RevMan 5.3进行Meta分析...

Systematic Evaluation of Compound Danshen Injection in the Adjuvant Treatment of Nephrotic Syndrome Based on Meta-Analysis

Objective:To systematically evaluate the efficacy and safety of Compound Danshen Injection in the adjuvant treatment of nephrotic syndrome.Methods:A total of 70 patients the databases of Wanfang,VIP,CNKI,CBM,Baidu academic,PubMed,The Cochrane Library and EMBASE were searched from the establishment of the database to May 2020.The required documents were searched according to the inclusion and exclusion criteria of the documents,the method quality was evaluated,and the software Revman 5.3 was used for meta-analysis.Results:A total of 10 articles on randomized controlled clinical trials were included,including 642 patients;In terms of comparison of changes in serum albumin:the treatment group was better than the control groupWMD=6.57,95%CI(4.35,8.78),P=0.00001].In terms of comparison of 24-hour urinary protein changes:there was no difference between the two groupsWMD=-1.52,95%CI(-3.61,0.57),P=0.15].In terms of comparison of blood creatinine changes:there was no difference between the two groupsWMD=-21.65,95%CI(-46.35,3.05),P=0.09].In terms of comparison of changes in cholesterol:the treatment group was better than the control groupWMD=-0.91,95%CI(-1.38,-0.44),P=0.0001].In terms of comparison of changes in whole blood viscosity:the treatment group was better than the control groupWMD=-0.7,95%CI(-0.79,-0.62),P<0.00001].In terms of comparison of the effective rate:the treatment group was better than the control groupOR=4.21,95%CI(1.62,10.94),P=0.003].Conclusion:Compound Danshen Injection can increase serum albumin,reduce whole blood viscosity and cholesterol in the adjuvant treatment of nephrotic syndrome.