银杏二萜内酯葡胺注射液联合氯吡格雷治疗冠心病合并脑梗死的疗效分析

目的探究银杏二萜内酯葡胺注射液联合氯吡格雷对冠心病合并脑梗死的疗效。方法选取2018年8月—2020年8月医院收治的冠心病合并脑梗死患者214例,采用随机数字表法分为联合组和对照组各107例。对照组患者采用氯吡格雷治疗,联合组采用银杏二萜内酯葡胺注射液联合氯吡格雷治疗,持续治疗7个疗程后,评估两组总有效率,治疗前后中医证候积分、简易智力状况检查评分(MMSE)及血小板聚集率,不良反应发生率。结果联合组临床治疗总有效率显著高于对照组(P<0.05);治疗后,两组中医证候积分与治疗前比较显著下降,对照组中医证候积分明显高于联合组(P<0.05);二磷酸腺苷(ADP)诱导下,两组血小板聚集率在治疗后均显著降低(P<0.05),血小板活化因子(PAF)诱导下,联合组治疗后血小板聚集率较治疗前显著降低(P<0.05),而对照组无显著差异(P>0.05);治疗后4周、12周,两组MMSE评分较治疗前显著上升(P<0.05)且两组组间比较差异有统计学意义(P<0.05);两组均无严重不良反应发生。结论银杏二萜内酯葡胺注射液联合氯吡格雷治疗冠心病合并脑梗死疗效确切,能有效改善患者动脉粥样硬化,安全性高。

Efficacy of Diterpene Ginkgolides Meglumine Injection Combined with Clopidogrel on Coronary Heart Disease Complicated with Cerebral Infarction

Objective To investigate the efficacy of Diterpene Ginkgolides Meglumine Injection combined with clopidogrel on cerebral infarction complicated with coronary heart disease. Methods A total of 214 patients with cerebral infraction and coronary heart disease in our hospital from August 2018 to August 2020 were enrolled and divided into two groups by random number table methods, each with 107 cases. The control group received clopidogrel, while the combined group received clopidogrel and Diterpene Ginkgolides Meglumine Injection. After 7 courses of treatment, the total effective rate, TCM syndrome score, Mini-Mental State Examination(MMSE) score, platelet aggregation rate and incidence of adverse reactions were evaluated. Results The total effective rate of the combined group was significantly higher than that in the control group(P<0.05). TCM syndrome scores were decreased in both groups after treatment(P<0.05), and were lower in the combined group than those in the control group(P<0.05). After induction of adenosine diphosphate(ADP), the platelet aggregation rate was decreased in both groups(P<0.05). After the induction of platelet activating factor(PAF),the platelet aggregation rate was significantly decreased in the combined group(P<0.05), while there was no significant change in the control group(P>0.05). At 4 and 12 weeks after treatment, MMSE scores were decreased in both groups(P<0.05), and were higher in the combined group than those in the control group(P<0.05). No serious adverse reactions occurred in both groups. Conclusion Diterpene Ginkgolides Meglumine Injection combined with clopidogrel is an effective treatment method for coronary heart disease complicated with cerebral infarction, with high safety.