六神胶囊联合磷酸奥司他韦胶囊治疗流行性感冒的临床研究

目的 探讨六神胶囊联合磷酸奥司他韦胶囊治疗流行性感冒的临床疗效.方法 选取2018年9月至2019年12月长沙市第一医院收治的156例流行性感冒患者,完全随机分为观察组和对照组,每组78例.对照组口服磷酸奥司他韦胶囊(75 mg/次,2次/d),观察组在对照组的基础上给予六神胶囊(0.15 g/次,3次/d),两组均治...

Clinical effect of Liushen Capsule combined with oseltamivir phosphate capsule in the treatment of patients with influenza

Objective To explore the clinical effect of Liushen Capsule combined with oseltamivir phosphate capsule in the treatment of patients with influenza. Methods A total of 156 patients with influenza admitted to The First Hospital of Changsha from September 2018 to December 2019 were selected and were randomly divided into observation group and control group, with78 cases in each group. The control group took oseltamivir phosphate capsule(75 mg/time, twice a day). The observation group took Liushen Capsule(0.15 g/time, three times a day) on the basis of control group. Both groups were treated for 5 days. When the temperature was higher than 38.5 ℃, the patients could take acetyl aminophenol tablets and the dosage was recorded. The clinical efficacy and the use of acetaminophen were compared between the two groups of patients, and the throat swelling and pain, cough, sniffling and body ache disappearance time were recorded. Serum levels of inflammatory factors CRP, TNF-α and IL-6 were detected before and5 days after treatment. Adverse drug reactions were observed in two groups. Results There was no significant difference between two groups in the effective rate of influenza treatment(P>0.05), but the cure rate of observation group was better than control group(P<0.05). During the treatment period, the disappearance time of throat swelling and pain, sniffling and body ache in observation group were shorter than those in control group(P<0.05). In addition, Liushen Capsule combined with oseltamivir phosphate capsule could also significantly reduce the use of acetyl aminophenol tablets in patients with influenza(P<0.05). Before treatment, there was no significant difference in the serum levels of CRP, TNF-α, IL-6 between the two groups(P>0.05);after 5 days of treatment, the serum levels of CRP, TNF-α, IL-6 in two groups were lowered, and the levels of these three inflammatory factors in observation group were lower than those in control group, the differences were statistically significant(P<0.05). The incidence of adverse drug reactions in the observation group and the control group were 7.69% and 5.12% respectively, and the difference was not statistically significant(P>0.05). Conclusion Liushen Capsule combined with oseltamivir phosphate capsule can effectively relieve the clinical symptoms of the patients with influenza, alleviate the inflammatory reactions, accelerate the recovery of the disease, shorten the duration of illness in influenza patients, and produce a better therapeutic effect than oseltamivir phosphate capsules alone.